Effect

Sentence Connectors Sentences Showing Cause/Effect Sentence connectors are words and expressions that interface sentences to help with comprehension. Sentence connectors are otherwise called connecting language. This connecting language can be utilized to arrange what you need to state, show resistance, give explanation, etc. In numerous punctuation books, you will discover data about sentence connectors when finding out about subjecting conjunctions, planning conjunctions, etc. Here are sentence connectors that show circumstances and logical results in composed English.â Kind of Connector Connector(s) Models Planning conjunctions for (cause), so (impact) Experts can in some cases be incredibly anxious, for their positions are now and again rather stressful.The specialist chose a subsequent feeling was required, so Tom was sent to an eye authority. Subjecting conjunctions since, since, as Since significant level positions are now and again rather distressing, experts can once in a while be incredibly impatient.Ive chosen to return to class on the grounds that Ive consistently needed to contemplate philosophy.As the gathering started late, the CEO went legitimately to his introduction on last quarters deals. Conjunctive verb modifiers in this manner, thus, therefore Significant level positions are on occasion rather unpleasant. In this way, experts can once in a while be amazingly impatient.Susan appreciated investing her free energy at the theater. Thus, she chose to get away in London so as to go to plays.The lease has expanded radically in the course of recent years. Thus, weve chose to move to a more affordable city. Relational words due to, due to, because of Because of the distressing idea of significant level positions, experts can once in a while be very impatient.Albert gone home early due to his meeting with his doctor.Many understudies burn through at least two hours playing computer games every day. Therefore, their evaluations endure and they once in a while need to rehash classes. Progressively About Sentence Connectors When you have aced the essentials of right use in composed English, you will need to communicate in increasinglyâ complex ways. Probably the most ideal approaches to improve your composing style is to utilize sentence connectors. Sentence connectors are utilized to communicate connections among thoughts and to consolidate sentences. The utilization of these connectors will add advancement to your composing style. Sentence connectors can accomplish more than show cause and result. Here is a short outline with instances of each kind of sentence connector and connections to more data. At the point when you need to give extra data: Not just have I not completed my work on the report, however I likewise need to start take a shot at one months from now introduction in New York which is very important.Mark might want to concentrate on his investigations one year from now. Likewise, he needs to search for a temporary job to improve his resume to help him in his future quest for new employment. Some sentence connectors demonstrate resistance to an ideaâ or show shock circumstances. Mary requested one more week to finish the task despite the fact that she had just gone through three weeks in preparation.Despite the monetary development of the previous eight years, most white collar class residents are having troublesome getting by.  Standing out data from connectors encourages you show the two sides of any contention: From one viewpoint, we havent put resources into foundation in the course of recent decades. Then again, charge incomes are at the most reduced in years.Unlike my French class, schoolwork in my business course is testing and interesting.â Subjecting conjunctions, for example, if or except if express conditions in different circumstances. On the off chance that we dont finish the undertaking soon, our manager will be extremely vexed and fire everyone!She chose to complete school in New York. Something else, shed need to move back home and live with her folks. Looking at thoughts, objects , and individuals is another utilization for these connectors: Similarly as Alice might want to go to workmanship school, Peter needs to go to a music conservatory. The showcasing office feels we need another include battle. Correspondingly, innovative work feel our items need a new methodology.

A Book Review of The Kissing Hand by Audrey Penn

A Book Review of The Kissing Hand by Audrey Penn Since it was first distributed in 1993, The Kissing Hand by Audrey Penn has given consolation to youngsters managing troublesome changes and circumstances. While the focal point of the image book is on fears about beginning school, the consolation and solace the book gives can be applied to a wide range of circumstances. Outline of The Kissing Hand The Kissing Hand is the narrative of Chester Raccoon, who is alarmed to tears at the idea of beginning kindergarten and being ceaselessly from his home, his mom and his standard exercises. His mom consoles him pretty much all the beneficial things he will discover at school, including new companions, toys, and books. The best part is that she reveals to Chester that she has a brilliant mystery that will cause him to feel at home at school. Its a mystery, went down to Chesters mother by her mom and to her mom by Chesters extraordinary grandma. The name of the mystery is the Kissing Hand. Chester needs to know more, so his mom shows him the mystery of the Kissing Hand. In the wake of kissing Chesters palm, his mom lets him know, Whenever you feel forlorn and need a bit of cherishing from home, simply press your hand to your chest and think, Mommy adores you. Chester is consoled to realize that his moms love will be with him any place he goes, even kindergarten. Chester is then motivated to give his mom a kissing hand by kissing her palm, which makes her upbeat. He at that point joyfully heads out to class. The story is marginally more grounded than the representations, which while bright, are not too executed as they could be. Be that as it may, children will see Chester as engaging in both the story and the representations. Toward the finish of the book, there is a page of little red heart-formed stickers that have the words The Kissing Hand imprinted on every one of them in white. This is a decent touch; instructors and advocates can give out the stickers subsequent to perusing the story to a class or guardians can utilize one at whatever point a youngster needs consolation. As indicated by her site, Audrey Penn was motivated to compose The Kissing Hand because of something shed seen and something she did accordingly. Shed seen a raccoon kiss the palm of her offspring, and afterward the fledgling put the kiss all over. At the point when Penns little girl was terrified about beginning kindergarten, Penn consoled her with a kiss to the palm of her girls hand. Her little girl was console, realizing the kiss would go with her any place she went, including school. About the Author, Audrey Penn After her profession as a ballet dancer reached a conclusion when she turned out to be sick with adolescent rheumatoid joint inflammation, Audrey Penn found another vocation as an essayist. Be that as it may, she started composing a diary when she was in the fourth grade and kept composition as she was growing up. Those early works turned into the reason for her first book, Happy Apple Told Me, distributed in 1975. The Kissing Hand, her fourth book, was distributed in 1993 and has become her most notable book. Audrey Penn got the Educational Press Association of Americas Distinguished Achievement Award for Excellence in Educational Journalism for The Kissing Hand. Penn has expounded on 20 books for youngsters. Taking all things together, Audrey Penn has composed 6 picture books about Chester Raccoon and his mom, each concentrating on an alternate circumstance that can be hard for a youngster to manage: A Pocket Full of Kisses (another infant sibling), A Kiss Goodbye (moving, setting off to another school), Chester Raccoon and the Big Bad Bully (managing a domineering jerk), Chester Raccoon and the Acorn Full of Memories (the passing of a companion) and Chester the Brave (beating fears), She likewise composed A Bedtime Kiss for Chester Raccoon, a load up book managing sleep time fears. Regarding why she expounds on creatures, Penn clarifies, Everyone can relate to a creature. I never need to stress over partiality or offending on the off chance that I utilize a creature rather than a person.â About the Illustrators, Ruth E. Harper and Nancy M. Hole Ruth E. Harper, who was conceived in England, has a foundation as a craftsmanship educator. Notwithstanding showing The Kissing Hand alongside Nancy M. Break, Harper showed Penns picture book Sassafras. Harper utilizes an assortment of media in her work, including pencil, charcoal, pastel, watercolor, and acrylic. Craftsman Nancy Leak, who lives in Maryland, is known for her printmaking. Barbara Leonard Gibson is the artist of all of Audrey Penns other picture books and board books about Chester Raccoon.â Audit and Recommendation The Kissing Hand has given a great deal of solace to terrified youngsters throughout the years. Numerous schools will peruse it to another kindergarten class to facilitate their feelings of dread. By and large, youngsters are as of now acquainted with the story and the possibility of the kissing hand truly reverberates with youthful ones. The Kissing Hand was initially distributed in 1993 by the Child Welfare League of America. In the foreword to the book, Jean Kennedy Smith, originator of Very Special Arts, composes, The Kissing Hand is a story for any youngster who faces a troublesome circumstance, and for the kid inside every one of us who now and again needs consolation. This book is ideal for kids 3 to 8 years of age who need soothing and consolation. (Tanglewood Press, 2006.) More Recommended Picture Books In the event that you are searching for sleep time stories for small kids that are consoling, Amy Hests Kiss Good Night, showed by Anita Jeram, is a decent suggestion, as is Goodnight Moon by Margaret Wise Brown, with delineations by Clement Hurd. For small kids stressed over beginning school, the accompanying picture books will help facilitate their feelings of trepidation: First Grade Jitters by Robert Quackenbush, with delineations by Yan Nascimbene, and Mary Ann Rodmans First Grade Stinks! represented by Beth Spiegel. Sources: Audrey Penns site, Tanglewood Press

Fall Transfer Update - UGA Undergraduate Admissions

Fall Transfer Update - UGA Undergraduate Admissions Fall Transfer Update Although I cannot give daily updates on what is happening with Fall transfer decisions, I will try to post a weekly update either on Thursday or Friday about the progress our office has made in reviewing Fall files. I will not be able to tell you when your file will be reviewed, what date is being reviewed (because it depends upon when a student applied, when the initial transcript was received, when the last transcript was received, and if we have all needed materials, etc.), or why an applicant has or has not heard yet. Our focus is on reviewing files, and we generally can make about 50-75 decisions a day, depending on how complicated the files are. As of this morning, we have roughly 2,500 fall transfer applications, and my estimate is that about 400 of these applications are incomplete (no transcript, missing transcript, out of date transcript, etc.). We have made decisions on about 750-800 files so far, and fall transfer decisions are our main focus at this time. At times, we may be pulled away for a day or so due to other issues, such as updated summer transfer materials right before summer orientation, or a furlough day (one is scheduled for 4/30). Please bear with us as we move forward with these applications, as we are working as quickly as possible to make decisions on these files.

Cutaneous Tuberculosis Disease - Free Essay Example

Sample details Pages: 19 Words: 5677 Downloads: 10 Date added: 2017/06/26 Category Health Essay Type Narrative essay Did you like this example? CHAPTER -1 CUTANEOUS TUBERCULOSIS INTRODUCTION: In this innovative world while progress in medicine has helped up to deal with many diseases Tuberculosis and Cutaneous Tuberculosis is still a challenge for doctors. A resurgence of Cutaneous Tuberculosis in areas of high HIV incidence, drug resistant present in patients with pulmonary tuberculosis and in immunosupressed patients are the main challenges for clinicians. (6) Cutaneous TB is caused by Mycobacterium tuberculosis, Mycobacterium bovis, Bacillus Calmette-Guerin (BCG) vaccinations and the Tuberculids whose pathogenesis is poorly understood. Don’t waste time! Our writers will create an original "Cutaneous Tuberculosis Disease" essay for you Create order Cutaneous TB is very variable in its clinical presentation, significance prognosis. Factors which effect on variability are: The pathogenesity of the organism involved. The Previous treatment given. The Immune status of the patients which can be related to the presence of Acquired Immunodeficiency Syndrome (AIDS) or Immunosuppressive therapy. The Port of infection. Any Local factors like, the recent Trauma, the lymphatic drainage, the vascularity of area and the proximity to lymph nodes). PREVALANCE: Thirty years ago it was assumed world wide that tuberculosis would be eradicated in the developed countries, as its incidence increased only on by average 6 % in the United States and 10% in Europe between the years 1953 and 1985. However, in 1983 tuberculosis was declared a global emergency by the world Health Organization because of a sharp increase in incidence. (9) Among infectious diseases, Tuberculosis is an important cause of death. Tuberculosis was responsible for 6% of deaths worldwide. Global prevalence of TB currently is greater than 32%. More than 50% of new patient occurrences were in 5 Asian countries, i.e. India (largest worldwide patient load), China, Indonesia, Bangladesh, and Pakistan(ref ?) The current global burden of Tuberculosis is mind boggling. In 1997, the incidence of new Tuberculosis patients approached 8 million in addition to more than 16 million patients already diagnosed. Around 2 million people died of Tuberculosis in 1997 with a global fatality rate of 23%, fatality rates exceed 50% in some African countries in which there is a high HIV incidence. Approximately 8% of tuberculosis patients are HIV infected. (2) Prevalence of tuberculosis infection in 1985, 1995 and 2005 (10) Prevalence of tuberculosis has increased between 1985 and 2005.According to the World Health Organization case reports statistics, in 1985 there were around 3 million patients of tuberculosis of all types with the highest no of cases in Asia and Africa. In Asia the highest numbers of cases were in India, Pakistan, China, Philippines, Bangladesh, Afghanistan and Vietnam. In Africa the highest number of case were in Ethiopia, Nigeria, South Africa, Congo, Morocco and Tanzania. (10) During the last two decades the number of cases increased all over the world. In 1995 the total number of cases increased to 4.6 million and in 2005 to 7.5 million worldwide. In Asia in 2005 the highest numbers of cases were in India, China Pakistan. In Africa in 2005 the highest numbers of cases were in South Africa, Ethiopia Congo. (10) There is an increasing rate of tuberculosis in the developing countries is approximately 500/100,000/y. Great alarm has been the progressive increase in numbers of strains of tuberculosis that are resistant to antibiotics. Since 1984, that incidence of extra pulmonary tuberculosis has increased at even faster rate than that of pulmonary tuberculosis and is considered to be a diagnostic criterion in the case definition for AIDS. Because immunocompromised individual are at increased risk of extra pulmonary tuberculosis, so dermatologist are renewing their historic role in the diagnosis of cutaneous lesions of tuberculosis. (11) EPIDEMIOLOGY: Epidemiological analysis is used to detect the changing trends in the incidence and prevalence of mycobacterial disease in the community. The main objectives of these methods are to determine the natural behavior of disease and factors which affect his behavior and to calculate future trend if possible to help in the design of any control measures and to assess the usefulness of these measure.(8) Even though 1 of 3 individuals on this planet is infected with tubercle bacillus, the incidence of Cutaneous TB appears low. In areas such as India or China where TB prevalence is high, cutaneous manifestations of TB (overt infection or Tuberculids) are found in less than 0.1% of persons seen in dermatology clinics. The frequency of patients with Cutaneous Tuberculosis seen between 1980 and 1993 in a hospital dermatology clinic in Madrid was 16 per 10,304 which was 0.14%. In a ten year retrospective survey of patients seen in governmental dermatology clinics in Hong Kong between 1983 and 1992, the detected incidence of Cutaneous Tuberculosis among patients was 179 per 267,089 which was 0.07%. Among patients with Cutaneous Tuberculosis only15% had classic Cutaneous Tuberculosis and 85% had tuberculids. In that classical cutaneous tuberculosis approximately 5% had lupus vulgaris, 5% had Tuberculosis Verrucosa cutis and 5% had scrofuloderma. (2) In a tertiary-care hospital in northern India, 0.1% of dermatology patients seen between 1975 and 1995 had Cutaneous Tuberculosis. Lupus vulgaris was the most common manifestation around 55%, followed by scrofuloderma 27%, TB Verrucosa cutis 6%, tuberculous gumma 5%, and tuberculids occurred in 7%. (2) FREQUENCY: USA: In the United States, tuberculosis cases decreased from 84,304 cases in 1953, when national reporting was first began, to 22,201 in 1985.   This represented fairly steady decline of about 5.8% per year. However, the turn down in tuberculosis cases stopped in between 1985 and 1992. In 1992 the annual number of cases increased by 20% to 26,673 cases. (12) The increases were concentrated geographically in several states, with over 90% of the 14,871 cases in California, Florida, New Jersey, New York, and Texas and demographically tuberculosi s occurred in racial and ethnic minorities, in people aged 25 to 44, males and in those born abroad. Especially troubling, and indicative of increasing transmission of new infections, was a 36% increase in tuberculosis among children 4 years old or younger. Tuberculosis appears to be on the decline again in the United States as numbers with only 14,871 cases in 2003. (12) Reported tuberculosis cases in United States, 1982-2002 (12) The percentage of Tuberculosis patients who were born abroad individuals was 42%. People born in Mexico, the Philippines, and Vietnam account for one half of born abroad Tuberculosis patients in the United States. The Tuberculosis rate among born abroad people was 4 to 6 times higher than for US-born peoples. Minimum estimates of the proportion of TB patients with coincident HIV infection were approximately 10-15%. Among people aged 25-44 years, this proportion increased to 20-30%. (12) The fundamental origin of this new Tuberculosis epidemic in troubled states reflects a minimum of four major factors including (1) the involvement of Tuberculosis with the HIV epidemic, (2) the increased migration from countries where Tuberculosis is common, (3) the spread of Tuberculosis in congested settings (health-care facilities, prisons, homeless shelters), and (4) the worsening of the basic health-care infrastructure. (2) Molecular typing of Mycobacterium tuberculosis isolates in the United States in a restriction fragment-length polymorphism study suggests more than one third of new patient incidence results from people-to-people transmission, and the remainder result from reactivation of latent infection. Approximately 1 of 13 Mycobacterium tuberculosis isolates currently shows a form of drug resistance. (2) The modern introduction of biological agents that block tumor necrosis factor-alpha in the treatment of rheumatoid arthritis, psoriasis, and several other autoimmune disorders has additional raised about the necessity of t he identification of patients with latent Tuberculosis. At present, several hundred cases of Tuberculosis have been reported in patients who receive these tumor necrosis factor-alpha antagonists. (2) HISTORY: Tuberculosis has an ancestry which can be traced to the earliest history of mankind. It was recognized as a contagious disease by the time of Hippocrates and Aristotle in 350 BC. Signs of skeletal Tuberculosis were identified in Europe since Neolithic times and in ancient Egypt around 3700 BC in mummified bodies. Evidence of TB appears in Biblical scripture, in Chinese literature dating back to around 4000 BC, and in religious books in India around 2000 BC. (5) During1600s and 1800s tuberculosis was known ass the Great White Plague in Europe.   Other names for Tuberculosis were Phthisis which was from Greek term phthinein, meaning to waste away, scrofula which were used for swellings of the lymph nodes of the neck and consumption which were used as progressive wastin g away of the body.(2) In 1826 Laennec first reported cutaneous tuberculosis which he called PROSECTOR WART. Following Laennec, Rokitansky and Virchow described the histological features in detail comparing them to those of visceral tuberculosis. (6) The Incidence of TB increased with population density and urban development so that by the Industrial Revolution in Europe in 1750, it was responsible for more than 25% of adult deaths. Indeed, in the early 20th century, TB was the leading cause of death in the United States. In 1882, a German biologist ROBERT KOCH presented his discovery of the organism that caused TB. NEIL FINSEN won the Nobel Prize in Medicine in 1903 for introducing UV light into the treatment of skin TB. (2) With the help of better living conditions and the introduction of the antibiotic streptomycin on 20th November 1944, the number of reported TB patients in the United States steadily declined around 126,000 TB patients in 1944, 84,000 in 1953, 22,000 in 1984, and 14,000 in 2004.(2) MODE OF TRANSMISSION: Tuberculosis is an airborne contagious disease that occurs after inhalation of infectious droplets expelled from patients with laryngeal or pulmonary Tuberculosis during coughing, sneezing, or speaking. Each cough can generate more than 3000 infectious droplets. Droplets are so small around 1 to 5 micro meter, that they remain airborne for hours. (2) The likelihood that disease transmission will occur depends upon the infectiousness of the tuberculous patient, the environment in which exposure takes place, and the duration of exposure. Roughly 20% of people in the infected household contact develop infection. Micro epidemics have occurred in closed environments such as transcontinental flights and submarines. Tuberculin sensitivity develops 2 to 10 weeks after infection and usually is lifetime. (2) Because Tuberculosis induces a powerful immune response, individuals with positive tuberculin reactions are at a considerab ly lower risk of acquiring new tuberculous infection. In HIV-infected individuals, active Tuberculosis is more likely to occur from reactivation of existing disease than from superinfection with a new mycobacterial strain. (2) Without treatment, an estimated 10% lifetimes possibility exists of developing active disease after tuberculous infection, 5% occurs within the first 2 years and 5% thereafter. An Increased risk of acquiring active disease occurs during HIV infection, Intravenous drug abuse, diabetes mellitus, silicosis, immunosuppressive therapy, cancer of the head and neck, hematological malignancies, end-stage renal disease, intestinal bypass surgery or gastrectomy, chronic malabsorption syndromes and low body weight. Infants younger than two years are associated with increased risk. (2) 1) DIRECT INHALATION: The most common mode of entry via portal in to the lungs usually resulting from the Inhalation of airborne droplets containing a few bacilli, expectorated by individuals with â€Å"open† pulmonary disease.(8) 2) INDIRECT INHALATION: A) Ingestion: Less often bacilli may be swallowed and lodge in to the tonsil or in the wall of the intestine. These infections are chiefly related to the consumption of contaminated milk products. (8) 3) INOCULATION: Cutaneous tuberculosis manifestations depend upon the method of cutaneous inoculations, which may be exogenous that is from an out side source, may occur by autoinoculation, or may be by endogenous .Direct exogenous inoculation in an individual not previously infected with tuberculosis causes primary tuberculosis infection, will led to the tuberculous ‘chancre or to tuberculosis Verrucosa cutis depending upon the immune status of the patient. Another example of exogenous transmission is lupus vulgaris at the site of BCG vaccination. (9) Endogenous transmission can occur by continuous extension of tuberculous process underlying the skin as in scrofuloderma, by the wa y of lymphatic as in lupus vulgaris and by hematogenous spread as in acute miliary tuberculosis or lupus vulgaris. (9) Infrequent mode of transmission is direct implantation in to the skin through cuts and abrasions. These troubles usually in persons, working with infected material or cultures of tubercle bacilli. These skin lesions were called as â€Å"Prosector warts† (8) CLASSIFFICATION OF CUTANEOUS TUBERCUCLOSIS: Cutaneous tuberculosis clinical manifestations comprise a considerable number of skin changes, usually sub classified in to more or less distinct disease forms. Classification depends on morphology more recently mode of transmission or the immunological state of host, but none of them satisfies completely. 1)INOCCULATION TUBERCUCLOSIS (Exogenous Source) Tuberculosis chancre Warty tuberculosis(Verruca cutis) Lupus vulgaris(some) 2) SECONDARY TUBERCULOSIS (Endogenous source) A) Contiguous spread Scrofuloderma B) Auto-inoculation Orifical tuberculosis 3)HAEMATOGENOUS TUBERCULOSIS Acute miliary tuberculosis Lupus vulgaris(some) Tuberculous gumma 4)ERUPTIVE TUBERCUCLOSIS (Tuberculids) A) Micropapular Lichen scrofulosorum B) Papular Papular/Papulonecrrotic TB C) Nodular Erythema induratum(Bazin) Nodular Tuberculids (CLASSIFICATION OF TUBERCULOSIS, MODIFIED FROM beyt et al) (4) CHAPTER-2 CLASSIFICATION OF MYCOBACTERIA: Tuberculosis is an infectious disease which is caused by the Mycobacterium species. Mycobacteria are acid fast, non-sporulating, non-motile weakly gram positive organisms. TEM micrograph of Mycobacterium tuberculosis Table 3: Kingdom Bacteria Phylum Actinobacteria Order Actinomycetales Suborder Corynebacterineae Family Mycobacteriaceae Genus Mycobacterium Scientific classification by Lehmann Neumann. (3) In 1950s Runyon classified the atypical mycobacteria according to their ability to form pigment, their rate of growth colony characteristics. This classification also includes obligate human pathogens and facultative human pathogens. (1) Today more then 60 species of mycobacteria are identified. Around 41 of these were included in the approved lists of bacterial names in 1980. (9) 30 species of mycobacterium are known that can cause disease in humans. The most common causative organism includes: Mycobacterium tuberculosis Mycobacterium Leprae. Atypical mycobacteria. The species which produce disease in tuberculosis primary complex include: Mycobacterium tuberculosis. Mycobacterium Bovis. Mycobacterium Africanum. Sometimes Bacillus Calmette Guerin (BCG) may also cause disease. (1) MEDICAL CLASSIFICATION: For the purpose of diagnosis treatment mycobacteria can be classified in several major groups. Mycobacterium tuberculosis complex, which can cause tuberculosis by the pathogens Mycobacterium tuberculosis, M Bovis, M Africanum M microti. Mycobacterium Leprae, which causes Hansens disease. Nontuberculous mycobacteria are the mycobacteria which can cause pulmonary disease, lymphadenitis, and skin disease disseminated disease. SLOW GROWING MYCOBACTERIA RUNYON GROUP 1)Obligate human pathogens M. tuberculosis-bovis group including bacillus Calmette-Guerin(BCG) M Africanum (not included in runyon classification 2)Facultative Human pathogens M. kansasii I M. marinum I M. simiae I M. scrofulaceum II M. szulgai II M. gordanae II M. avium-intracellualr complex III M. haemophilum III M. Ulcerans III M. xenopi III 3) Nonpathogens M. flavescen II M. terrae complex III M. trivale III M. gastri III RAPIDLY GROWING MYCOBACTERIA 1))Facultative Human pathogens M. fortuitum I V M. chelonae I V M. abscessus I V 2) Nonpathogens M. smegmatis I V M. phlei I V M. vaccae I V others STAINING CHARACTERISTICS OF MYCOBACTERIA: Mycobacteria are aerobic, facultative, intracellular non-spore forming and non-motile curved rods measuring 0.2- 0.5 by 2-4 um. Mycolic acid rich long chain glycol lipids and phospholipoglycans, a mycocides present in the cell wall of mycobacteria protect them. (2) Mycobacteria do not gram stain readily but their most valuable staining characteristic is Acid Fastness. This ability retains carbol fuchin dye after washing with acid or alcohol occurs because of the high content of cell wall mycolic acids, fatty acids other lipids. Other staining methods used include Dietrele, auramine-Rhodamine and phenolic acridine orange stains. Nocardia rhodococcus, legionella dadei, isospora cryptosporidium also share acid fastness. (1) The Ziehl-Neelson acid-fast stain, while highly specific for mycobacteria, is relatively insensitive, and recognition requires at least 10,000 bacilli per mL; most clinical laboratories currently use a more sen sitive auramine-rhodamine fluorescent stain (auramine O). Routine culture uses a nonselective egg medium called Lowenstein-Jensen or Middlebrook 7H10 and often requires more than 3-4 weeks to grow because of the 22-hour doubling time of mycobacterium tuberculosis. Radiometric broth culture, BACTEC radiometric system of clinical specimens significantly reduces time 10 to 14 d for mycobacterial recovery. DNA probes specific for mycobacterial ribosomal RNA categorize species of clinically significant isolates after recovery. In tissue, polymerase chain reaction (PCR) amplification techniques can be used to detect Mycobactereria tuberculosis-specific DNA sequences and thus, small numbers of mycobacteria in clinical specimens. (2) The cell wall of mycobacteria consist of: (3) Outer lipids Mycolic acid Polysaccharides(arabinoglactan) Peptideglycan Plasma membrane. Lipoarrabinomannan(LAM) Phosphatidylinositol mannoside. Cell wall skeleton. PATHOGENESIS: The most common site for Tuberculosis disease is lungs and 85% of TB patients present with pulmonary symptoms. The most common sites of extrapulmonary disease are mediastinal, retroperitoneal, and cervical lymph nodes, vertebral bodes, adrenals, meninges, and the GI tract. Pathology of these lesions is similar to those in the lung. Extrapulmonary TB can occur as part of a primary or late generalized infection or as a reactivation site that may, coexist with pulmonary reactivation. (2) Mycobacterium tuberculosis is an obligate pathogen. It is a slender aerobic rod, characterized by high lipid content. This lipid is responsible for resistance to phagocytosis. Identification of organism is easy in tuberculous chancre, scrofuloderma, orificial lesions and the miliary variant. This may be difficult to find or absent in lupus vulgaris, gummata and warty tuberculosis. The organism is highly resistant to drying to drying and therefore can retain infectivity by inocula tion or contamination of minor wounds. (19) The reaction of the bacterium depends on: the size of inoculum. the virulence of organism. The immune state of patient. After mycobacteria have invaded the host, either they may multiply and caused progressive infection or their multiplication is checked or completely arrested. The balance between bacterial multiplication and damage is depend not only properties of the invading organism but also by the ability of the host to control such infection. (9) Once the bacteria have invaded, the interaction of T-lymphocyte and mycobacteria antigens, displayed on the surface of antigen presenting cells, induces the liberation of lymphokines, interlukins and intereferons. These substances encourage the activation and expression of MHC molecule II antigens and IL-2R on T-Lymphocytes. Macrophages gather and a granuloma is formed. During the initial sensitization T cells generated and these will remain for decades in affected organ and the circulation. (6) In HIV infection, cell mediated immunity is impaired and therefore there may be reactivation of disease. (6) With the onset of host-immune response, lesions that develop around mycobacterial foci can be either proliferative or exudative. Both types of lesions develop in the same host, since infective dose and local immunity differ from site to site. (2) Proliferative lesions develop where the bacillary load is small and host cellular-immune responses dominate. These tubercles are condensed with activated macrophages admixed and are bounded by proliferating lymphocytes, plasma cells, and an outer rim of fibrosis. Intracellular killing of mycobacteria is effective, and the bacillary load remains low. (2) Exudative lesions predominate when large numbers of bacilli are present and host defenses are weak. These loose aggregates of immature macrophages, neutrophils, fibrin, and caseation necrosis are sites of mycobacterial growth. Without treatment, these lesions progress and infection spreads. (2) Even though mycobacteria are spread by blood all over the body during initial infection, primary extrapulmonary disease is rare e xcept in severely immunocompromised hosts. Resistant hosts control mycobacterial growth at distant foci before expansion of active disease. Infants, older persons, or otherwise immunosuppressed hosts are incapable to control mycobacterial growth and develop disseminated Tuberculosis. Patients who become immunocompromised months to years after primary infection also can develop late generalized disease. (2) HISTOLOGY: The tubercle is the feature of the tuberculosis and infections with some of the atypical mycobacteria. In early stages of the skin lesion there is non specific inflammation but tubercle formation occur with in a month. (20) A tubercle granuloma consists of foci of epitheloid cells, containing variable, but usually sparse number of langerhans giant cells, with surrounding by a rim of mononuclear cells. The centre of this tuberculoid granuloma may shown a caseation necrosis which may calcify. (20) Even though tuberculoid granuloma is highly characteristic for several forms tuberculosis, but it is not pathognomic. Syphilis, leprosy, deep fungal infection and some other disease can also produce similar type of lesions. However differentiation of tuberculosis from these conditions sometimes may not be easy. (20) MICROSCOPIC ASPECTS: The involvement of an organ by tuberculosis is related with an inflammatory reaction at the affected site. There are three consecutive stages of inflammation, which are acute, subacute and chronic. These stages have different histological aspects. (21) 1) THE ACUTE PHASE: Infection first leads to a rapid, nonspecific inflammatory reaction apparent by exudative lesions, which are not predominantly specific to tuberculosis. The focus of inflammation is the site of serous-fibrous exudates with abundant macrophages in the centre. (21) 2) THE SUBACUTE PHASE: Lysis of the bacilli liberates the phospholipids from their capsule, provoking a specific tissue reaction and the formation of follicles  "Koester follicles†. Two kinds of follicular lesions may be observed. (21) A) The epitheloid giant cell follicle: These are rounded focus containing numerous epitheloid cells, which are monocyte with egg-shaped centre, abundant cytoplasm and indistinct cytoplasmic edges. Several Langhans giant cells, generally situated din the centre of the follicle. These are large cells with abundant cytoplasm, indistinct edges and multiple centres arranged in the shape of a crown or horseshoe. Langhans cells are formed by the fusion of epitheloid cells. Epitheloid cells and langhans cells created by the monocyte, under the action of lymphokines. There is also a peripheral crown of lymphocytes. (21) This follicle does not contain necrosis and is not specific for tuberculosis. It is common to tuberculous leprosy, sarcoidosis and connective tissue diseases. (21) B) The necrotizing granuloma: The epitheloid giant cell follicle presents with central Caseating necrosis. This lesion is very specific for tuberculosis. Caseating necrosis is a fine-grained, homogeneous eosinophilic necrosis. (21) 3) THE CHRONIC PHASE: The tuberculous follicle gradually develops in to a fibrous follicle. Collagenous fibres invade the tuberculous focus, which is enclosed in a fibrous shell with fibroblast and lymphocytes; forming a fibro-Caseating follicle that is then transformed into a fully fibrous follicle this follicle can become entirely calcified. (21) The key examination for confirming the diagnosis of tuberculosis is bacteriology. Histology does play an important role in confirming diagnosis of extra pulmonary tuberculosis. Combination of both histological techniques and bacteriology increase the yield of histology. (21) MICROBIOLOGY: Tubercle bacilli are aerobic, with lipid-rich walls and a slow rate of growth. They take 20 hours on average to double in number. The lungs, dark and oxygen rich, at a temperature of 37 °C, provide an ideal environment for th e bacilli to replicate .Tubercle bacilli are rapidly destroyed in the ambient environment by ultraviolet rays. It is difficult to stain the bacilli with stains commonly used for other bacteriological examinations. They require special stains that can penetrate the wax-rich wall of the bacillus. For bacteriological examination, the quality of the samples sent to the laboratory is of fundamental importance. For pulmonary tuberculosis: The specimen that should be collected for examination is sputum obtained from the patient after coughing; more rarely the sample is obtained by gastric aspiration or bronchoscopy. As sputum can be contaminated by other bacteria, it must be collected in clean sputum non-sterile containers that can be firmly sealed. For extrapulmonary tuberculosis: Fluid from serous effusion, cerebrospinal fluid or biopsied fragments can be sent to the laboratory for culture. All sampling must be performed in strictly sterile conditions so that culture can b e performed directly without prior decontamination. Samples must never be placed in formol, which kills the bacilli. bacteriological techniques Microscopy A smear of a selected part of a submitted specimen is made on a slide, then examined by microscope after staining †¢ Staining methods There are several staining methods used for the tubercle bacillus; it is important for the method or methods used to be standardized for each country. The stains that are the most effective are Ziehl-Neelsen (ZN) staining and auramine staining. Ziehl-Neelsen staining The smear is covered with carbol fuchsin, and then heated. The smear is then destained successively using sulfuric acid and alcohol. All of the smears must be almost totally destained, and then restained with methylene blue. The bacilli are stained red by the fuchsin and are resistant to the acid and alcohol, hence the name acid-fast bacilli (AFB). Destaining by the successive application of acid and a lcohol can also be done using only 25% sulfuric acid; however, it should be applied several times until the smear is completely destained. This is the method recommended by the IUATLD, as it is less delicate and does not require alcohol (which is not always available in some countries). On microscopic examination of the stained smear, the tubercle bacilli look like fine, red, slightly curved rods that are more or less granular, isolated, in pairs or in groups, and stand out clearly against the blue background. Fluorescent auramine staining The fuchsin is replaced by auramine; the bacilli fix the fluorescent stain and retain it after the acid and alcohol staining. †¢ Reading by microscopy After Ziehl-Neelsen staining The stained smear is examined using a binocular microscope with an immersion lens (magnification  ¥100). The number of AFB per 100 fields ,about one length and one width of a slide are counted. This technique is simple, rapid and fairly in expens ive. After auramine staining The stained smear is examined by fluorescence microscopy with a dry lens of low magnification (*25 or 40). This microscope has an ultraviolet lamp to enable the fluorescent bacilli to be seen: they are clearly visible in the form of greenish-yellow fluorescent rods. The sensitivity and specificity of examination by fluorescence microscopy are comparable to those of microscopy after ZN staining. The main advantage is the easy and rapidity of reading: on the same slide surface, the results of 10 minutes reading by optic microscope are obtained in 2 minutes on fluorescence microscopy. As this technique requires more costly equipment (the microscope itself, and the lamps, which need to be replaced frequently ,on average after 200 hours of use, it is cost-effective only if more than 30 slides are examined each day. A constant electricity supply and trained technicians are also indispensable CHAPTER -3 TYPES OF CUTANEOUS TUBERCULOSIS: INTRODU CTION: Scrofuloderma and lupus vulgaris are the two most common forms of tuberculosis. However, the pattern of cutaneous tuberculosis is changing, as the tuberculid, lichen scrofulosorum, is becoming more common over recent years and has occurs almost as frequently as scrofuloderma and lupus vulgaris. 1) SCROFULODERMA: Syn- Tuberculosis colliquativa, scrofulous gumma. DEFINITION: Scrofuloderma is a subacute form of subcutaneous tuberculosis which causes cold abscess formation and secondary breakdown of overlying skin. PATHOGENESIS: Scrofuloderma results from the contiguous involvement of the skin overlying another tubrculous process for example, tuberculous lymphadenitis, tuberculosis of bone and joints, or tuberculous epididymitis. (9) INCIDENCE: Scrofuloderma may affect all groups but historically, a high prevalence of scrofuloderma was seen in children infected with Mycobacterium bovis from contaminated nonpasteurized milk (which type cow ). CLINICAL FEATURES: Lesions present as firm, painless, subcutaneous nodules that progressively enlarge and suppurate and then form ulcers and sinus tracts to the overlying skin. Typical ulcers have undermined edges and a floor of granulation tissue. Typical tubercles with acid-fast bacilli are found in the lower dermis and the walls of the ulcer or abscess. Tubercle bacilli usually can be isolated from the purulent discharge. Tuberculin sensitivity is usually marked. Natural healing can occur but often takes years and may be accompanied by the formation of hypertrophic scars. Lupus vulgaris may develop in the locality of healing scrofuloderma. (2) Cervical lymph nodes are infected most commonly on the same side of the neck as the primary tuberculous complex. In the neck submandibular, preauricular, tonsillar, postauricular, occipital and supraclavicular lymph nodes are usually implicated. Occasionally discharging sinuses may occur over areas devoid of lymph nodes. Over weeks to mont hs the involved lymph nodes enlarge, turn livid red, suppurate and then perforate with resultant ulceration and fistula formation. (11) Progression of disease with scarring produces irregular adherent masses, densely fibrous in places and fluctuant or discharging in others. Fungating tumors may arise from the excessive granulation tissue and after healing characteristic puckered scaring at the site of the infection. (4) COURSE: Spontaneous healing does occur (what % ? ) but it takes years before it is a completed. The typical cribriform or criss-crossed scarring and localized recurrence are common. 2) LUPUS VULGARIS: Syn: Tuberculosis cutis Luposa DEFINITION: In most reporting publication, Lupus Vulgaris is the most common form of Cutaneous TB and has the most unpredictable presentation. Lupus vulgaris is a chronic and progressive form of Cutaneous TB that occurs in tuberculin-sensitive patients. Hypersensitivity to tuberculin is high although immunity is low to moderate. (11) The mode of infection is not entirely clear in the individual case but it is considered that Lesions appear in normal skin either as a result of direct extension of underlying tuberculous foci, in lymphatic or hematogenous spread, after primary inoculation, after BCG vaccination, or in the scars of old scrofuloderma. INCIDENCE: Traditionally, lupus vulgaris was most common in northern Europe and less common in Asian countries ( figures), with affected females outnumbering males by 2-3:1. All age group affected equally. (2) CLINICAL FEATURES: Lesions are small, sharply marginated; red-brown papules of gelatinous consistency called apple-jelly nodules. This apple-jelly nodule slowly evolves by peripheral extension in to large plaques with central atrophy. Lesions are frequently solitary, and more than 90% involve the head and neck. Re-emergence of new active tuberculosis nodules within earlier atrophic or scarred lesions is characteristic. If the Cart ilage of the nose and ears is involved, it is gradually destroyed. This destruction of tissue is known as lupus vorax. Bone usually is spared. Buccal, nasal, and conjunctival mucosa may be involved primarily or by extension. (2) Lupus Vulgaris is more common in western countries on the face, especially on cheeks, nose, ears, and on the extensor surface of the extremities, also on the breast buttocks. In many developing countries including India the lower extremities mainly the buttocks are the primary site of involvement. Mucous membrane involvement is very rare in Lupus Vulgaris. (11) VARIANTS OF LUPUS VULGARIS: There are many clinical types depending upon the local tissue response to infection. 1- PLAQUE FORM OR LUPUS VULGARIS EXFOLIATIVE: This form of lupus vulgaris is characterized by the plaques. Scaling frequently occurs on the lower legs where it may resemble psoriasis. As the lesion enlarges they become softer. Over a period of time a polycystic or serpiginou s configuration can develop with central clearing and atrophy in the lesion. Irregular scarring is frequent and the active edge may be thickened and hyperkeratotic. (2) 2) ULCERATING AND MUTILATING LUPUS VULGARIS: Scarring and ulceration be the main clinical features. Crusts form over areas of necrosis. Deep tissues and cartilage are invaded and ultimate scarring of the disease produces contractures and distortion. (2) 3) LUPUS VULGARIS VEGETANS OR LUPUS PAPILLOMATOSUS: This form of lupus vulgaris is characterized by necrosis, ulceration, and proliferative and papillomatous granulation tissue. It involves mucous membranes sometimes, and invades and destroys the cartilage when involving nasal and auricular cartilage. (2) 4) NODULAR FORM OF LUPUS VULGARIS: In this form of lupus vulgaris large soft tumors appears usually on ear lobes. These are characterized by an absence of ulceration and scarring. (2) 5) LUPUS POSTEXANTHEMATICUS: It is disseminated, papular an d nodular form that commonly arises after a transient impairment of immunity predominantly after measles.(9) ( complete lesion picture) 6) LUPUS VULGARIS OF MUCOUS MEMBRANE: Mucous membrane tuberculous lesions are extremely rare. These lesions are small soft, gray or pink papules, ulcers or granulating masses that bleed easily. They arise in mucous membrane by direct extension of skin lupus to buccal, nasal or conjunctival mucosa. This form can produce severe destruction can produce stenosis of the larynx and scarring deformities. (9) DIAGNOSIS OF LUPUS VULGARIS: Lupus vulgaris is difficult to diagnose when it occur in unusual sites like popliteal fossa. Special stains and mycobacterial cultures may be having frequently negative in these sites. However, it is possible to reach the correct diagnosis of Lupus vulgaris by using clinical and histopathological findings. In such cases, to confirm the diagnosis at times, a therapeutic trial with antitubercular agents may be re quired. (17) COURSE: Lupus vulgaris is a very destructive disease and without treatment can progress slowly over years or even decades. It can cause severe scarring and disfigurements like Ectropion, and others distortion of the mouth and severe damage to the nose may occur. (11) CUTANEOS TUBERCULOSIS IN CHILDREN: Cutaneous tuberculosis in children is a most important health problem in India. It accounts for about 1.5% of all the cases of extra pulmonary tuberculosis Overall the clinical patterns are comparable with adults. However, children can have widespread and severe involvement because many unusual and infrequent patterns are known to occur in children. Underlying systemic involvement(what invovlment) is more common in children with lupus vulgaris, compared to adults with lupus vulgaris. (13) Cutaneous tuberculosis is extensive in Pakistan but has not been adequately documented. One study was conducted to establish the clinical patterns, incidence and prevalence of the disease in Larkana, Sindh province, Pakistan. This study showed the number of patients was reasonably has large, thus suggesting a high incidence of cutaneous tuberculosis in Larkana. Lupus vulgaris, a form of cutaneous tuberculosis, was extensive in this area and prevalent in adults, while scrofuloderma was prevalent in children. Additionally, the obtainable rate of the disease was higher in children aged under ten years of age and lower in adults. This showed that children are more prone to this disease than adults in Larkana.(complete ratio of patients) (14) Ocular scrofuloderma with orbital tuberculosis is a rarely described presentation of childhood tuberculosis. Bilateral eye involvement had never been reported. One case report from India,in which a three year old boy who presented with bilateral infraorbital swellings of tubercular etiology. Computed tomography (CT) scan of the upper face revealed enhanced soft tissue lesions in both the lower lids of the eyes, wit h extraconal extension into the orbits and with erosion of the right zygomatic bone. The cause was confirmed by using the Ziehl Neelsen staining of the aspirate from the lesions, which was positive for acid-fast bacilli and growth of Mycobacterium tuberculosis in the aspirate culture. The patient showed marked improvement of his lesions on anti-tubercular treatment. (15) Localized tuberculid has been reported occasionally in the data. The majority of these case reports are of papulonecrotic tuberculid localized to the penis, an entity selected as penis tuberculid. In females, such a localized genital tuberculid has not been reported frequently. There is one case report from India, in which an 11-year-old girl with lichen scrofulosorum confined to the vulva, associated with cervical and inguinal tubercular lymphandenitis is reported. (16) UNUSUAL MANIFESTATION OF TUBERCUCLOSIS: Long standing lupus vulgaris can be complicated by Squamous cell carcinoma. Latency period may be 10- 20 years. I am presenting a case report from Romania in which 59 years old farmer lady had lupus vulgaris on right ear lobule, since childhood. which started after her empiric perforation for earrings. The development was progressive, strange, involving the pinna and the right cheek in the meantime. At the time of first examination, a diffuse mass of red-yellowish infiltration was found at the level of the right ear and the right cheek. In the following two years, an ulcer-vegetating tumor developed at the level of the right ear lobule, along with retromandibular adenopathy, of about 1 cm, histopathological examination confirmed the diagnosis of squamous cell carcinoma developed from a lupus vulgaris. (18)

Frankenstein Essay - 1176 Words

Many people know that Mary Shelley, the author of Frankenstein, was part of a family of famed Romantic era writers. Her mother, Mary Wollstonecraft, was one of the first leaders of the feminist movement, her father, William Godwin, was a famous social philosopher, and her husband, Percy Shelley, was one of the leading Romantic poets of the time (Frankenstein: Mary Shelley Biography.). What most people do not know, however, is that Mary Shelley dealt with issues of abandonment her whole life and fear of giving birth (Duncan, Greg. Frankenstein: The Historical Context.). When she wrote Frankenstein, she revealed her hidden fears and desires through the story of Victor Frankenstein’s creation, putting him symbolically in her place†¦show more content†¦In a fit of passion he destroyed the unfinished female creature, so that it could not kill him. This is the manifestation of Shelley’s repressed desire to never give birth to another child. The first creature, i n anger at the loss of a future mate, took revenge on Victor. The creature led his creator across the globe and through terrain in which Victor could not survive. This chase lasted several months, ending in the Arctic Circle, and caused the death of his creator. Another recurring theme is that of the child abandoned by the parents. Elizabeth, before being adopted into Victor’s family, was abandoned by her birth parents- her mother had died, and her father was in jail. Victor’s closest friend, Henry Clerval, was mainly neglected by his father. Henry’s father was â€Å"a narrow-minded trader and saw idleness and ruin in the aspirations and ambition of his son† (54). He denied Henry an education, though Henry wished more than anything to accompany Victor at the university. Lastly, Victor left his creature shortly after giving him life. The creature can be said to be a representation of Shelley’s id, a manifestation of all her suppressed feelings (Hicks, Elizabeth. Psychoanalytic Criticism and Frankenstein.). He is utterly alone in the world, having been left by his creator- the one person who should care for him and be responsible for him. He is as miserable as Shelley must have felt at beingShow More RelatedFrankenstein And Frankenstein Essay1474 Words   |  6 Pagesfictional characters, most famously in John Milton’s Paradise Lost, in 1667, and Mary Shelley’s Frankenstein, in 1818. The complexity of the characters in these texts creates the theme of nature versus nurture before they diverge and arrive at differing conclusions. Many critics arose over the years to contest the main character of Milton’s epic. Shelley, arguably Milton’s greatest critic, wrote Frankenstein to contrast her views on the conflict between creator and creation. She also uses an unconventionalRead MoreCritical Essay On Frankenstein1219 Words   |  5 Pages Frankenstein Critical Essay In the book Frankenstein by Mary Shelley an often debated topic is: who is responsible for the murders throughout the novel? The story is all based around how Frankenstein creates a monster in his laboratory. This monster is made of old human body parts, and Frankenstein brings it to life. The monster is unable to fit into society and he is called ugly often. Throughout the novel the monster just wants to fit in and be accepted by others. Frankenstein being hisRead MoreFrankenstein essay 2 672 Words   |  3 Pagesï » ¿ Frankensteins Monster and Miltons Satan An Essay on Paradise Lost and Frankenstein By Chris Davidson Almost all great works of literature contain allusions to other great works of literature that enhance the meaning of the work. Mary Shelly’s Frankenstein is an excellent example of a major literary work that contains a sustained allusion to another major work. Frankenstein contains many references to Milton’s Paradise Lost, and the two stories are parallel in many aspects. In Shelly’sRead MoreEssay on Frankenstein986 Words   |  4 Pageslife from a new perspective. The only thing the creature wants is a companion who understands exactly how he feels and who would love him for who he was, and not hate him for what he didn’t look like. nbsp;nbsp;nbsp;nbsp;nbsp;In the novel Frankenstein, Mary Shelley does an excellent job at challenging the traditional ideas of race, class, and cultural privilege. She allows the readers to view life from a perspective that most do not get to see. It is one that is completely rejected by societyRead More Frankenstein Essay584 Words   |  3 Pages Frankenstein nbsp;nbsp;nbsp;nbsp;nbsp;In the book Frankenstein, by Mary Shelley, the two main characters, Victor and the monster have completely different personalities and the expectation of their actions are very different from what one would imagine. When Victor’s project of the monster finally comes to life, Victor gets scared and runs away from it, showing the readers how he is a very selfish man. The monster and Victor spend two years away from each other until the monster finds VictorRead More Frankenstein Essay572 Words   |  3 Pages In Marry Shelley’s Frankenstein, the powerful creature represents the physical manifestation of the ugliness and selfishness of Victor’s desires as well as being the solution for his need to escape from the elements that threaten his way of life. Victor chose to embark on the arduous task of creating what he perceived as perfection. To him, this creation was intended to be both intelligent and powerful, immortal and beautiful. He was seeking the perfect humanoid entity that he thought would beRead MoreSublime In Frankenstein Essay1497 Words   |  6 Pagesirony [1] . The Castle of Otranto is the first Gothic novel written by Horace Walpole in which the idea of the Sublime is presented through its physical, transcending and overpowering imagery. This experience is also illustrated in Mary Shelley s Frankenstein; both novels explore the idea and concept of the Sublime and show the theoretical notions through its characters and themes conveyed. I will examine the features of the genre by looking at the imagery which is presented by the writers in orderRead MoreFrankenstein Application Essay1036 Words   |  5 PagesFrankenstein Application Essay, Writing Assignment 5 Can science go too far when it equips man with tools to manipulate life? Some of the underlying ethical dilemmas presented in Mary Shelley’s Frankenstein are similar to ones we struggle with today, such as selective abortion. Shelley’s doomed creature mirrors the devastating result of bringing an unwanted offspring into the world, then shirking responsibility for it thereafter. The practice of playing God and choosing who does and who doesRead MoreFrankenstein Essay655 Words   |  3 Pagescontributions to mankind, ultimately some scientific endeavors should never have been pursued. In Frankenstein, Mary Shelly explores the ethics involved in this query through the creation of a wonder of science, and its inevitable consequences. Much of the analysis of the consequences that the scientific perversion of nature harbors is manifested by the inner struggle within both Dr. Frankenstein and his monster. The tortured mind of the creator expresses the notion that one who plays god willRead More FRANKENSTEIN Essay754 Words   |  4 PagesFRANKENSTEIN In the story â€Å"Frankenstein,† written by the author Mary Shelley, Victor Frankenstein decided that wanted to create a being out of people that were already dead. He believed that he could bring people back from the grave. Playing with nature in such a way would make him play the role of God. With Victor Frankenstein feeling that he had no true friends, the only relief he had of expressing his feeling was through letters to Elizabeth. Elizabeth was not Victors’ true sister but

Food Habits Changing After Food, Inc Free Essays

The documentary Food, Inc was created to show viewers what is being put on their plates and has given me an altered view towards the food industry which has drastically changed my food habits. Many emotional scenes were shown on this film to give viewers empathy towards the problem that is occurring. The documentary shows many vivid details and explains what is in the food that consumers eat. We will write a custom essay sample on Food Habits Changing After Food, Inc or any similar topic only for you Order Now The film food, Inc influenced my habits of consumption by eating organic meats, purchasing most foods in the farmers market, and checking for food labels. I have learned that there is a big difference in organic and non-organic meats. Animals raised organically are not allowed to be fed antibiotics or other drugs and cannot eat genetically modified foods. Eating organic meats is not only helping animals but also preventing the consumer from a possible disease outbreak that may occur due to the mistreatment of animals. The meat comes from a sustainable farm that uses the manure productively as organic fertilizer. The manure is â€Å"pure,† coming from animals fed an organic diet which ensures consumers that there will not be any exposure to chemicals. Consumers feel safe knowing that the certified organic meat won’t hurt them in the long-run. Going to a farmers’ market helps consumers because everything is fresh, locally grown, and certified organic which gives the buyer no doubts. When purchasing meat from an organic farm stand at a farmer’s market, consumers support that farm. On the other hand, buying non-organic meat that isn’t local, free-range, or ranch-raised from a supermarket chain will most likely support a multinational food corporation. After the experience change in some of the famers’ supermarkets, I also started realizing the foods tasted better and after eating, I felt lighter and full at the same time. I also saw that costs were higher than the farmers’ markets but it truly made a difference to purchase organic produce and meats. It decreased health risks like diabetes and obesity. Food labels are essential to consumers because they stay alert with what they eat everywhere they go. I have always wondered how many calories are in the food in restaurants as well as other types of foods that I buy at the grocery store. Most restaurants don’t list the actual nutritional value of their food which is why it’s important for consumers’ to remember to check and be aware of what is going to be in their bodies. The film transmits this message to its viewers by showing consumers foods that have glucose and Trans fat than expected. There can be many ingredients or a high number of calories that a consumer may not know about but after looking at a label, it will give the consumer peace of mind or change their mind on whether they will eat it or not. Food, Inc helped me realize and understand that it’s critical for consumers to be cautious about how different foods can affect their overall health. This led me to change some of my eating habits such as buying organic meats, which helped me choose my foods wisely. Being aware lets consumers like me stay healthy. Food, Inc taught me a lot about buying organic animal products because it’s better for health, the community, and it can also benefit consumers in the long-run. I would recommend that all consumers watch this film and understand the positive aspects of it because it gives some critical points about the food industry and backs them up with evidence. Food is important for the body and it helps an individual survive every day, but it can also be deadly. It’s all about making the right decisions when it comes to the consumers’ food habits. How to cite Food Habits Changing After Food, Inc, Essays

Witch Of Wall Street - Hetty Green Essays - Economy,

Witch Of Wall Street - Hetty Green The Witch of Wall Street A musical based on the life of America's first great female financier, Hetty Green After watching the play, The Witch of Wall Street, and giving it a lot of thought I have analyzed the questions we were given and decided that just answering one wouldn't do the play or the storyline any justice. Therefore I have decided to run through the play in segments answering all five questions in the process of doing so. 1- Describe the plot of the play. 2- Describe the obstacles and opportunities Hetty Green had in the result of her success. 3- What were the main benefactors and antagonizers. The lifetime accomplishments of Hetty Green all started at a young and tender age when she would hang around the docks her father owned, where she was instilled with a certain attitude towards business. She was quite a tomboy, understanding the lingo of the whalers and learning the business. She was her fathers pride and joy, quick to numbers, always giving him the answers he wanted. Her mother, who was an ill and frail woman, was unhappy that she wasn't like other girls her age. While her father blamed her mother for not even being able to produce a son, Hetty, mature and sensitive for her age continued to only do one thing; be the best in her father's eyes. Competitiveness, the need to be successful and the desire to be only the best reigned her persona. Hetty's mother warned her daughter that her father was a shrewd and selfish man. She made sure to tell Hetty that when she died, the entire business would belong to her, despite her father's words? She warned her daughter not to trust anyone, while Hetty would cry to her, promising to make her happy, be rich and successful and buy her mother a beautiful big house. After her mother died, Hetty was introduced to the cold brutality of the world and it was the first notch of trust she lost in her father. Right after the funeral the lawyer announced that all assets would belong to Robinson. Hetty protested to her father questioning what would happen to his promise of Robinson and Daughter? To which her father, aptly - as was his ability to do, turned the entire scenario around, first slapping her and throwing a huge guilt trip on her, which made her apologize for not trusting him? Robinson and Daughter would do just fine in his hands? As Hetty grew older, watching the docks, little did sh e realize that her father was scheming and running the business according to his desire without consulting her. One day as she was watching the big ships with her father, she noticed something odd and questioned where they were going? After her father tried to dodge the question for a little bit by marveling at how pretty and tall she has become, he answered sheepishly that they were going to be sunk and sold for the war efforts. This was an investment for himself (as he thought) for after the war. Hetty is struck by a forceful thought; she can never trust anyone. This part of her growing up had a major effect on the way she conducted her business. Hetty grew up with a protective shell, juggling the balls in a way to keep both her parents happy, having to keep up with her father's ridiculous expectations. He himself wasn't able to keep his word; she lost trust in him at a young age. When Hetty grew older and attended a school for fine young girls she was quick to realize that she was an outcast, she had no social skills, she had no interest in the petty things other girls her age wanted and was on an extremely different wavelength than the rest of them. This formed her to a greater extent. She was a tough nut to crack and for one reason ? she learned that the best defense against the world was beating them at their own game. Hetty was still unmarried at the age of twenty-five. Once again, her father, the cunning shrewd man that he was, got her to play his game, and set her